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The Hepatitis B Research Network brings together clinical centers with expertise in caring for patients with chronic hepatitis B virus (HBV) infection. An estimated 2 billion people worldwide have been infected with HBV and about 400 million persons are living with chronic HBV infection. Of those with childhood-acquired chronic HBV infection, it is estimated that 25% will later die from the liver-related complications of cancer and cirrhosis if left untreated. The prevalence of HBV infection is uneven throughout the world, with significant burdens in Asia and the Pacific Islands, sub-Saharan Africa, the Amazon Basin, and Eastern Europe. National surveys indicate that 0.3% to 0.5% of U.S. residents have chronic HBV infection, and 47% to 70% of these persons were born outside the United States. The goal of the Network is to conduct research on chronic hepatitis B, in order to better understand the physiological effects of the disease and develop effective treatment strategies with the currently available therapies.

This web site is designed to inform the public of the research activities conducted by the Hepatitis B Research Network. It is also a portal to support communications for our researchers and participants in our studies.

Adult Enrolling Cities Ann Arbor, MI Michigan Hawaii Consortium University of Michigan Health System City: Ann Arbor, MI Contact: Sravanthi Kaza Phone: 734-615-3853 Email: sravanth@med.umich.edu Link: www.umclinicalstudies.org University of Hawaii/Hawaii Medical Center East City: Honolulu, HI Contact: Richmond Wong Phone: 808-691-7609 Fax: 808-691-1169 Email: riwong@queens.org Boston, MA Harvard Beth Israel Deaconess Medical Center (BIDMC) City: Boston, MA Contact: Jianghe Niu Phone: 617-632-1119 Fax: 617-632-1125 Email: jniu@bidmc.harvard.edu Massachusetts General Hospital City: Boston, MA Contact: Nifasha Rusibamayila Phone: 617-726-3670 Email: NRUSIBAMAYILA@mgh.harvard.edu Bethesda, MD NIH Clinical Center City: Bethesda, MD Contact: Elenita Rivera Telephone: 301-435-6125 Fax: 301-451-9160 Email: erivera@cc.nih.gov Contact: Marc Ghany Phone: 301-402-5115 Fax: 301-402-0491 Email: marcg@intra.niddk.nih.gov Chapel Hill, NC Chapel Hill, NC University of North Carolina at Chapel Hill City: Chapel Hill, NC Contact: Tamara Jones Phone: 919-843-5732 Fax: 919-843-4558 Email: Tamara_jones@med.unc.edu Duke University Medical Center City: Durham, NC Contact: Tina Lucas Phone: 919-668-1679 Fax: 919-668-6110 Email: tina.lucas@duke.edu Dallas, TX HBV CRN North Texas University of Texas Southwestern City: Dallas, TX Contact: Jody Rule Phone: 214-645-6113 Fax: 214-645-6114 Email: jody.rule@utsouthwestern.edu Link: http://www.utsouthwestern.edu/patientcare/medicalservices/digestive/liver.html Baylor University Medical Center City: Dallas, TX Contact: Barbara Lilly Phone: 214-820-1778 Fax: 214-820-7142 Email: Barbara.Lilly@BSWHealth.org Children’s Medical Center Dallas City: Dallas, TX Contact: Allison Johnson Phone: 214-456-6761 Email: allison.johnson@childrens.com Contact: Norberto Rodriguez-Baez Phone: 214-456-8000 Email: Norberto.Rodriguez-Baez@childrens.com Durham, NC Chapel Hill, NC University of North Carolina at Chapel Hill City: Chapel Hill, NC Contact: Tamara Jones Phone: 919-843-5732 Fax: 919-843-4558 Email: Tamara_jones@med.unc.edu Duke University Medical Center City: Durham, NC Contact: Tina Lucas Phone: 919-668-1679 Fax: 919-668-6110 Email: tina.lucas@duke.edu Honolulu, HI Michigan Hawaii Consortium Queen's Medical Center - Liver Center City: Honolulu, HI Contact: Richmong Wong Phone: 808-691-7609 Fax: 808-691-1169 Email: riwong@queens.org University of Michigan Health System City: Ann Arbor, MI Contact: Sravanthi Kaza Phone: 734-615-3853 Email: sravanth@med.umich.edu Link: www.umclinicalstudies.org Los Angeles, CA Los Angeles Hepatitis B Consortium - UCLA - Enrollment closed Cedars Sinai Medical Center - Enrollment closed Minneapolis, MN Minnesota Alliance for Research in Chronic Hepatitis B (MARCH-B) - Mayo Clinic Mayo Clinic - Enrollment closed University of Minnesota - Enrollment closed University of Minnesota Amplatz Children's Hospital City: Minneapolis/St Paul, MN Contact: Sarah Jane Schwarzenberg, MD Phone: 612-624-1133 Fax: 612-626-0639 Email: schwa005@umn.edu Richmond, VA Virginia Commonwealth University Medical Center City: Richmond, VA Contact: Richard Sterling Phone: 804-828-4060 Fax: 804-828-4945 Email: rksterli@vcu.edu Rochester, MN Minnesota Alliance for Research in Chronic Hepatitis B (MARCH-B) - Mayo Clinic Mayo Clinic - Enrollment closed University of Minnesota - Enrollment closed University of Minnesota Amplatz Children's Hospital City: Minneapolis/St Paul, MN Contact: Sarah Jane Schwarzenberg, MD Phone: 612-624-1133 Fax: 612-626-0639 Email: schwa005@umn.edu St. Louis, MO St. Louis Midwest Hep B Consortium Saint Louis University City: St. Louis, MO Contact: Kathryn Rushing Phone: 314-977-9320 Fax: 314-977-1210 Email: kathryn.rushing@health.slu.edu Saint Louis University (Pediatric site) City: St. Louis, MO Contact: Rosemary Nagy Phone: 314-268-2700 x 6144 Fax: 314-268-2775 Email: rosemarynagy@health.slu.edu Contact: Jeffrey Teckman Phone: 314-577-5647 Fax: 314-268-2775 Email: Jeff.Teckman@health.slu.edu Washington University City: St. Louis, MO Contact: Mauricio Lisker-Melman Phone: 314-454-8141 Email: mlisker@dom.wustl.edu Link: http://gastro.wustl.edu Contact: Mike Klebert Phone: 314-747-1098 Fax: 314-361-5231 Email: mklebert@dom.wustl.edu Contact: Lisa Kessels Phone: 314-747-1096 Email: lkessels@dom.wustl.edu San Francisco, CA San Francisco Hepatitis B Research Group University of California San Francisco City: San Francisco, CA Contact: Ashley Shobe Phone: 415-514-2859 Fax: 415-502-0500 Email: aungermann@medicine.ucsf.edu University of California San Francisco (Pediatric site) Contact: Natasha Feier Phone: 415-476-1539 Fax: 415-476-1343 Email: natasha.feier@ucsf.edu California Pacific Medical Center City: San Francisco, CA Contact: Stewart Cooper Phone: 415-600-1548 Fax: 415-600-1200 Email: stewartcooper@sbcglobal.net Seattle, WA PNW/Alaska Clinical Center Harborview Medical Center - Enrollment closed Virginia Mason Medical Center - Enrollment closed Seattle Children's Hospital City: Seattle, WA Contact: Karen Murray Phone: 206-987-4592 Fax: 206-987-2721 Email: Karen.murray@seattlechildrens.org Toronto, ON University of Toronto Toronto Western Hospital Liver Centre City: Toronto, ON Contact: Colina Yim Phone: 416-603-5976 Fax: 416-603-7175 Email: colina.yim@uhn.on.ca Hospital for Sick Children City: Toronto, ON Contact: Simon Ling Phone: 416-813-6176 Fax: 416-813-6531 Email: simon.ling@sickkids.ca

Pediatric Enrolling Cities Baltimore, MD Johns Hopkins School of Medicine City: Baltimore, MD Contact: Kathy Schwarz, MD Phone: 410-955-0781 Email: kschwarz@jhmi.edu City: Baltimore, MD Contact: Naureen Islam Phone: 410-955-9161 Fax: 410-614-1820 Email: nislam5@jhmi.edu Dallas, TX HBV CRN North Texas University of Texas Southwestern City: Dallas, TX Contact: Jody Rule Phone: 214-645-6113 Fax: 214-645-6114 Email: jody.rule@utsouthwestern.edu Link: http://www.utsouthwestern.edu/patientcare/medicalservices/digestive/liver.html Baylor University Medical Center City: Dallas, TX Contact: Barbara Lilly Phone: 214-820-1778 Fax: 214-820-7142 Email: Barbara.Lilly@BSWHealth.org Children’s Medical Center Dallas City: Dallas, TX Contact: Allison Johnson Phone: 214-456-6761 Email: allison.johnson@childrens.com Contact: Norberto Rodriguez-Baez Phone: 214-456-8000 Email: Norberto.Rodriguez-Baez@childrens.com Minneapolis, MN Minnesota Alliance for Research in Chronic Hepatitis B (MARCH-B) - Mayo Clinic Mayo Clinic - Enrollment closed University of Minnesota - Enrollment closed University of Minnesota Amplatz Children's Hospital City: Minneapolis/St Paul, MN Contact: Sarah Jane Schwarzenberg, MD Phone: 612-624-1133 Fax: 612-626-0639 Email: schwa005@umn.edu St. Louis, MO St. Louis Midwest Hep B Consortium Saint Louis University City: St. Louis, MO Contact: Kathryn Rushing Phone: 314-977-9320 Fax: 314-977-1210 Email: kathryn.rushing@health.slu.edu Saint Louis University (Pediatric site) City: St. Louis, MO Contact: Rosemary Nagy Phone: 314-268-2700 x 6144 Fax: 314-268-2775 Email: rosemary.nagy@health.slu.edu Contact: Jeffrey Teckman Phone: 314-577-5647 Fax: 314-268-2775 Email: teckmanj@slu.edu Washington University City: St. Louis, MO Contact: Mauricio Lisker-Melman Phone: 314-454-8141 Email: mlisker@dom.wustl.edu Link: http://gastro.wustl.edu Contact: Mike Klebert Phone: 314-747-1098 Fax: 314-361-5231 Email: mklebert@dom.wustl.edu Contact: Lisa Kessels Phone: 314-747-1096 Email: lkessels@dom.wustl.edu San Francisco, CA San Francisco Hepatitis B Research Group University of California San Francisco City: San Francisco, CA Contact: Ashley Shobe Phone: 415-514-2859 Fax: 415-502-0500 Email: aungermann@medicine.ucsf.edu University of California San Francisco (Pediatric site) Contact: Natasha Feier Phone: 415-476-1539 Fax: 415-476-1343 Email: natasha.feier@ucsf.edu California Pacific Medical Center City: San Francisco, CA Contact: Stewart Cooper Phone: 415-600-1548 Fax: 415-600-1200 Email: stewartcooper@sbcglobal.net Seattle, WA PNW/Alaska Clinical Center Harborview Medical Center - Enrollment closed Virginia Mason Medical Center - Enrollment closed Seattle Children's Hospital City: Seattle, WA Contact: Karen Murray Phone: 206-987-4592 Fax: 206-987-2721 Email: Karen.murray@seattlechildrens.org Toronto, ON University of Toronto Toronto Western Hospital Liver Centre City: Toronto, ON Contact: Colina Yim Phone: 416-603-5976 Fax: 416-603-7175 Email: colina.yim@uhn.on.ca Hospital for Sick Children City: Toronto, ON Contact: Simon Ling Phone: 416-813-6176 Fax: 416-813-6531 Email: simon.ling@sickkids.ca