Ancillary Studies



The Hepatitis B Research Network (HBRN) is a NIDDK-funded network of 28 Clinical Sites, an Immunology Center and a Data Coordinating Center (DCC). The goals of the network are to study the natural history, pathogenesis, diagnosis and treatment of chronic hepatitis B in children and adults. The HBRN has implemented a longitudinal observational database of children 2-17 years, a longitudinal observational database of adults at least 18 years of age and three treatment trials for chronic hepatitis B in adults or children. There are sera, plasma, and DNA specimens available at protocol-determined timepoints.

The HBRN invites submission of ancillary study proposals that explore questions and test hypotheses that are relevant to the goals and purposes of the HBRN but are not addressed by HBRN funded core protocols. While ancillary studies generally utilize information about, or specimens obtained from, participants already enrolled in a HBRN network study, they may involve additional patients. Ancillary studies may also involve non-HBRN study sites, investigators, specimen or data collection, procedures, or treatments. It is the responsibility of the investigator(s) to procure funding to cover the costs of an ancillary study. Ancillary studies must include a HBRN investigator to be considered. The HBRN Ancillary Studies process is not intended to be a mechanism to support pilot studies.

Below you will find an overview of the HBRN Ancillary Studies Process and a downloadable Ancillary Studies Proposal form. Please feel free to contact the DCC at HBRNDCC@edc.pitt.edu to obtain more information.

Ancillary Studies Proposal Form »